528A:
Correlation of Antibiotic Allergy Frequency and Problematic Diagnoses
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Thomas Bebekoski, Carl B. Lauter, MD FAAAAI, Matthew Sims
RATIONALE: After noting that inpatients who had consultations placed to Infectious Diseases for choice of therapy given multiple antibiotic allergies frequently carried diagnoses associated with a preponderance of somatic complaint, we undertook to analyze the association between the number of reported allergies and such diagnosis.

METHODS: For the year 2015 all inpatients at Beaumont Royal Oak, Troy, and Grosse Pointe were reviewed for antibiotic allergies and total number of allergies listed in the EPIC electronic medical record. The problem list and past medical history were obtained for each of these patients. Diagnoses and number of reported allergies were examined to determine the correlation between the numbers of reported allergies and various diagnoses.

RESULTS: For the year 2015, 35,304 unique patients were identified with any reported allergy, of which 19,284 had a reported antibiotic allergy. The number of reported allergies varied from 1 to 62; 5828 reported a single allergy (30.22%), 908 reported ≥10 allergies (4.71%), and 114 reported ≥20 allergies (0.59%). There was a strong association between multiple allergies and fibromyalgia and interstitial cystitis. There was a neutral association between multiple allergies and fracture, lymphoma, anxiety, and GERD.

CONCLUSIONS: Patients with diagnoses associated with a high number of somatic complaints have a high correlation with reported allergy number. This potentially leads to inferior treatment of a true infection due to limits imposed on antibiotic choice based on allergy history. Careful determination of whether a reported allergy is a true allergy is needed to improve treatment in these patients.