METHODS: Retrospective study of electronic medical records of patients with CSU exacerbated by NSAIDs, attended at a tertiary hospital. Patients without a history of exacerbation or who did not know the use or worsening of symptoms with NSAIDs were excluded. Acute respiratory symptoms triggered by NSAIDs and chronic respiratory symptoms, concomitant with CSU, were assessed.
RESULTS: A total of 92 patients were assessed, being 90% female, mean age of 52 years and disease duration of 12.9 years. The most common NSAIDs were dipyrone (65.2%) and diclofenac (33.7%). The history of acute respiratory symptoms associated with the cutaneous condition after exposure to NSAIDs was present in 12 patients (13%), being denominated patients with mixed hypersensitivity reactions or "blended reactions". Acute respiratory symptoms were more frequent in patients with chronic respiratory disease. Of these patients with blended reactions 75% had chronic rhinitis, 41.7% had asthma and, 18.2% had nasal polyps.
CONCLUSIONS: The present study showed that 13% of patients with NSAIDs exacerbated-CSU also presented acute respiratory symptoms after the use of NSAIDs, being more frequent in those patients with chronic respiratory disease, including chronic rhinitis, asthma and nasal polyps.