536:
Characterization of Aeroallergens Sensitization And Atopy In The Pediatric Population Of Puerto Rico
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Wilfredo Cosme-Blanco, MD PhD, Lorena Gonzalez-Sepulveda, MS, Veronica Solivan-Vargas, MD, Anardi Agosto-Mujica, MD, Sona Rivas-Tumanyan, DMD DrPH, Sylvette Nazario, MD
RATIONALE: Sensitization to aeroallergens during childhood could lead to the development and progression of allergic rhinitis, asthma, and atopic dermatitis. There are no studies about sensitization to aeroallergens in the pediatric population of Puerto Rico. Our aim is to determine the prevalence of aeroallergens and their association with atopy.

METHODS: Retrospective chart review of 400 patients (ages 1 to 18) who underwent skin prick test to 54 aeroallergens from three geographically different allergy clinics was performed. Socio-demographic information, atopy, serum total IgE and absolute eosinophil count (AEC) were assessed. Age-and-sex adjusted odds ratios (AOR) and 95% confidence intervals (CI) were estimated to determine association between atopy and aeroallergen sensitization using logistic regression.

RESULTS: Seventy-eight percent of patients were sensitized to at least one aeroallergen and 70% to two or more. Sensitized patients had median serum IgE and AEC of 706 IU/mL (Interquartile range [IQR]=205, 1518) and 400 cells/mL (IQR=200, 567), respectively. Among those sensitized, 86% were sensitized to dust mites, followed by cockroaches (38%), and ants (24%). Allergic rhinitis, asthma, and atopic dermatitis were observed in 94%, 49%, and 23% of the patients, respectively. Patients with dust mites sensitization had higher odds of presenting atopic dermatitis (AOR=1.98, 95%CI:1.13-3.48) and rhinitis (AOR=3.43, 95%CI:1.28-9.22) than their counterparts. Cockroach sensitization was associated to all atopy manifestations after age and sex adjustment (p<0.05).

CONCLUSIONS: The studied population is mostly polysensitized with high levels of IgE and AEC. Dust mites, the main sensitizing aeroallergen, was associated to rhinitis and atopic dermatitis. Cockroach sensitization was associated to all atopy manifestations.