Systemic lupus erythematosus (SLE) is considered associated with angioedema (AE). Nationwide epidemiological studies in hospital settings are lacking.
METHODS: We conducted a cross-sectional study on the association between SLE and AE using data from National Inpatient Sample (NIS) in 2014. Diagnoses were identified using ICD-9-CM codes. Hospitalizations with a diagnosis of AE and SLE were included. Chi-square and student t-test were used for univariable analysis and logistic regression was used for multivariable analysis after adjusting age, gender, race, insurance, atopic diseases (allergic rhinitis, atopic dermatitis and asthma), anaphylaxis, leukocytoclastic vasculitis (including urticarial vasculitis), infections, eosinophilia and deficiencies of circulating enzymes (including C1-INH deficiency) as well as systemic comorbidities including hypertension, diabetes, coronary artery disease, heart failure, COPD, chronic kidney disease/glomerular disease, and chronic liver disease.
30,303 hospitalizations with a diagnosis of AE and 191,665 hospitalizations with a diagnosis of SLE were identified among a total of 35,358,818 hospitalizations in the US in 2014. Compared to those without SLE, AE patients with SLE were younger (47 vs 58, p < 0.0001), more female (87% vs 56%, p < 0.0001), and more African-American (58 vs 37, p < 0.0001). SLE was associated with increased odds of AE (unadjusted OR 3.40, 95%CI 2.80 - 4.13, p < 0.0001, adjusted OR 2.68, 95%CI 2.18 - 3.28, p < 0.0001)
Our nationwide study shows that hospitalizations with a diagnosis of SLE are over 3 times more likely to have AE compared to those without SLE.