333:
A comparison of the utilities of the fractional exhaled nitric oxide level and mannitol bronchial provocation test in terms of predicting exercise-induced bronchoconstriction in asthmatic children
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Yeong-Gwan Im, Man Yong Han, Sun Hee Choi, MD, Heysung Baek, MD
RATIONALE: We compared the diagnostic utilities of the fraction of exhaled nitric oxide (FeNO) test and mannitol bronchial provocation test (BPT) in terms of predicting exercise-induced bronchoconstriction (EIB) in asthmatic children.

METHODS: We retrospectively analysed data from 60 asthmatic children aged 6–16 years. We compared the exercise BPT results, FeNO levels, and mannitol BPT data. All cases were divided into exercise-positive or -negative BPT groups (n=41, 19, respectively).

RESULTS: Of the 41 exercise-positive patients, 32 and 9, respectively, were mannitol BPT-positive and -negative. Of the 19 exercise-negative patients, 9 and 10, respectively, were mannitol BPT-positive and -negative. The maximum %forced expiratory volume in 1 s (FEV1) decreases after exercise were positively correlated with the FeNO level (r=0.556, P<0.001), the mannitol response-dose ratio (RDR; r=0.416, P=0.001). The receiver operating characteristic (ROC) curve for the FeNO level discriminating between asthmatics with and without EIB had an area under the curve (AUC) of 0.771 (95% CI=0.643–0.870). The discriminatory ROC curve for the mannitol RDR had an AUC of 0.763 (95% CI=0.633–0.864). The AUCs of the FeNO level and mannitol RDR did not differ significantly.

CONCLUSIONS: EIB was significantly correlated with both the FeNO level and mannitol BPT data. Both methods similarly predicted EIB in asthmatic children.