Longitudinal observation of non-specific bronchial hyperresponsiveness in school children: The role of the Atopy
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Sun Hee Choi, MD, Kyung Suk Lee, MD, Yeong-Ho Rha, Hannah Jang

Many cross-sectional studies have related bronchial hyperresposiveness(BHR) and atopy in children. However, there have been a few longitudinal studies. In this study, we investigated the role of atopy in school age on change over time in bronchial hyperresponsiveness


In a longitudinal observational study in children of mean age of 10.5 with recurrent cough and wheezing during preceding 1 year, data were collected on atopy, total IgE, eosinophil count, familial history for allergic diseases and lung function from children with two methacholine bronchial challenge tests by ATS guideline over 1 year, retrospectively. BHR was defined to be 16mg/mL or less. Atopy was considered to be positive specific IgE for antigen one or more.


Total 78 children were recruited and 45 children were atopic. Atopic children had higher prevalence in bronchial hyperresponsiveness. (P=0.048, P=0.004) In methacholine challenge after 1 year, atopic children have higher prevalence for BHR than nonatopic children. (P=0.011)


Atopy at school age appeared to be of critical importance in predicting the course of BHR during school aged children. Atopy might be predictive factor for persistent BHR.