334:
Longitudinal observation of non-specific bronchial hyperresponsiveness in school children: The role of the Atopy
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Sun Hee Choi, MD, Kyung Suk Lee, MD, Yeong-Ho Rha, Hannah Jang
RATIONALE:

Many cross-sectional studies have related bronchial hyperresposiveness(BHR) and atopy in children. However, there have been a few longitudinal studies. In this study, we investigated the role of atopy in school age on change over time in bronchial hyperresponsiveness

METHODS:

In a longitudinal observational study in children of mean age of 10.5 with recurrent cough and wheezing during preceding 1 year, data were collected on atopy, total IgE, eosinophil count, familial history for allergic diseases and lung function from children with two methacholine bronchial challenge tests by ATS guideline over 1 year, retrospectively. BHR was defined to be 16mg/mL or less. Atopy was considered to be positive specific IgE for antigen one or more.

RESULTS:

Total 78 children were recruited and 45 children were atopic. Atopic children had higher prevalence in bronchial hyperresponsiveness. (P=0.048, P=0.004) In methacholine challenge after 1 year, atopic children have higher prevalence for BHR than nonatopic children. (P=0.011)

CONCLUSIONS:

Atopy at school age appeared to be of critical importance in predicting the course of BHR during school aged children. Atopy might be predictive factor for persistent BHR.