Intranasal Association of Fluticasone propionate/Azelastine hydrochloride is Effective in Children with Allergic Rhinitis
Saturday, March 3, 2018
South Hall A2 (Convention Center)
Nelson Augusto Rosario, MD PhD FAAAAI, Tatiane gs Scaliante, Cristine S. Rosario, MD, Herberto J. Chong Neto, MD PhD FAAAAI, Carlos a Riedi
RATIONALE: This intranasal anti-histamines and/or corticosteroids are effective in controlling allergic rhinitis symptoms (AR) but may interfere with skin prick tests (SPT). The aim of this study was to verify efficacy of intranasal Fluticasone propionate/Azelastine hydrochloride (FLU/AZE) in AR as well as SPT inhibition.

METHODS: Randomized single-blind trial to compare the outcomes of FLU/AZE, Fluticasone propionate (FLU) and Azelastin hydrochloride (AZE), 1 puff per nostril each bid for four weeks in 6 year-old children with AR. All patients had total nasal score symptom (TNSS) ≥ 8 (moderate to severe AR) and positive SPT to D. pteronyssinus (Dp) extract. SPT were carried on with histamine 10mg/mL and Dp 10000 PNU/mL and saline. TNSS and SPT were performed before (V1) and after (V2) four weeks of treatment.

RESULTS: Forty-five patients, 63% male, mean age11.3±1.7 years, were randomized to FLU/AZE (n=15), FLU (n=13) and AZE (n=15). One children dropped-out and other did not show up V2 in the FLU group. After four weeks, the mean TNSS reduction was higher in FLU/AZE group (58.2%) than FLU (48.2%) and AZE (44.4%) groups (p=0.02). The mean wheal size reduction in the SPT for histamine was higher in the FLU/AZE group (31.3%) than FLU (13.2%) and AZE (27.3%) groups (p=0.0008). There were no difference between groups in mean wheal size reduction for Dp, FLU/AZE (36.4%), FLU (21.7%) and AZE (31.6%), (p=0.09).


the association of intranasal FLU/AZE was more effective than intranasal corticosteroids or anti-histamine isolated, and promote more SPT inhibition in children.