METHODS: We collected information from the National Health Insurance Service insurance claims database from 2006 to 2015. The total children and adolescent (n=5,626,328) were eligible for our study. From these participants, we aimed to investigate exposure period of antibiotics prior 7 year affects development of allergic diseases. The diagnostic codes are L20 for atopic dermatitis, J301, J302, J303, and J304 for allergic rhinitis, J45 and J46 for asthma. Analysis was performed using three models for adjusting for confounding factors including age, sex, health care visit days, income, and region of residence (urban/rural).
RESULTS: Patient proportion of allergic diseases was more dominant with male and children (age<10) (all p<0.0001). Also, urban living and higher income people prone to developed allergic diseases (all p<0.0001). Annual mean antibiotics prescription days of antibiotics showed significant differences between each allergic disease group and comparison group (all p<0.0001). As exposure duration of antibiotics increased, allergic diseases including atopic dermatitis, asthma, and allergic rhinitis incidence also showed an increasing trend using multiple logistic regression, even after confounding factor adjustment model (p for trend<0.0001).
CONCLUSIONS: Antibiotic use in the earlier life is associated with an increased risk of allergic diseases especially in the young children, and the risk is showed duration-dependent elevation. Moreover, urban resistant showed more strong association with exposure duration.