841:
Pre-filled Syringes For Immunoglobulin Therapy: A Pragmatic Review Of Clinical Experience From Other Disease Settings
Monday, March 5, 2018
South Hall A2 (Convention Center)
Ayman R Kafal, PhD, Donald C Vinh, MD, Mélanie J Langelier, MSc
RATIONALE: Immunoglobulin G (IgG) replacement is an established treatment for patients with primary and secondary immunodeficiencies. Measures to improve patient experience and quality of life remain important goals of individualized IgG treatment regimens. The introduction of pre-filled syringes, widely used in other clinical conditions, addresses an unmet need that may offer significant benefits to patients.

METHODS: A pragmatic literature review of articles published in PubMed was conducted to collate the experience from other clinical settings on the use of pre-filled syringes. The primary search term was “(pre-filled or prefilled) AND syringe[MH]”; no time constraint was imposed. Results were filtered to focus on articles reporting data from clinical and comparative studies. Further articles were identified by searching specific terms of interest.

RESULTS: The primary search identified a total of 229 articles, covering diverse disease areas. Of these, 69 articles were clinical or comparative studies. Data from the subset of relevant articles reported bioequivalence, stability, efficacy, and safety of drugs delivered by pre-filled syringe. Evidence also showed that the use of pre-filled syringes, which eliminate drug preparation steps, significantly reduces drug/infusion treatment time. In studies reporting the responses of patients and healthcare professionals, the acceptability, usability, convenience, and preference for the use of pre-filled syringes were generally high. Potential for cost savings were reported in some, but not all, studies.

CONCLUSIONS: Current evidence from other clinical settings demonstrates the advantages of pre-filled syringes for treatment and improved patient experience, which supports their use and potential benefits to patients receiving IgG therapy.