Chronic spontaneous urticaria and autoimmunity: a follow up study of patients with chronic urticaria for 16 years.
Saturday, March 3, 2018
South Hall A2 (Convention Center)
Claudia Castilho Mouco, Andressa Zanandréa, João Paulo de Assis, MD, Raisa Borges Castro, MD, Gabriella Melo Fontes Silva Dias, MD, Jorge Kalil, MD, PhD, Antonio Abilio Motta, Rosana C. Agondi, MD, PhD
RATIONALE: Approximately 40% of patients with chronic spontaneous urticaria (CSU) have a concomitant autoimmune disease. In addition, CSU is associated with the presence of IgG anti-IgE or IgG anti-high affinity receptor for IgE in about 50% of patients. The aim of this study was to evaluate the frequency of autoimmune disease (AID) and/or autoantibodies in outpatients with chronic spontaneous urticaria during a period of 16 years.

METHODS: Retrospective study of the electronic medical record of adults outpatients with CSU, attended at a tertiary hospital between 2000 and 2016. The presence of AID or autoantibodies concomitant with CSU and if CSU diagnosis preceded or followed AID were assessed.

RESULTS: This study assessed 988 patients with CSU. AID and/or autoantibodies were present in 143 patients (14.5%). Of these, 88.1% were female, the mean age was 53.3 years and the mean time of CSU was 12.1 years. Of the 143 patients, 64 (44.8%) had AIDs, the most prevalent were hypothyroidism or hyperthyroidism. Autoantibodies without AID were present in 79 patients (55.2%). CSU preceded (mean time of 11.5 years) the diagnosis of AID in 24 patients (37.5%) and CSU developed after AID diagnosis (mean time of 5 years) in 29 patients (45.3%). CSU concomitant to AID was diagnosed in 11 patients (17.2%).

CONCLUSIONS: The link between CSU and AID isn’t yet fully understood, however, several studies showed a high prevalence of this association. In this study, the association between CSU and AID and/or autoantibodies was observed in 14.5% of the patients over a 16-year period.