Autoantibody profile in treatment naïve Takayasu arteritis patients
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Maja Stojanovic, MD, Sanvila Raskovic, Dragana Jovanovic, Jasna Bolpacic, Aleksandra Peric Popadic, Ivan Rankovic, Vladimir Milivojevic, Mirjana Bogic
RATIONALE: Takayasu arteritis (TA) is autoimmune arteritis of unknown etiology. Occasionally, autoantibodies and organ-specific autoimmune diseases (OSAD) may appear in TA patients. The aim of our study was to investigate presence of autoantibodies (AB) and OSAD in patients with TA and healthy controls.

METHODS: Sera of 24 treatment naïve TA patients and 40 controls were tested for Antinuclear (ANA), Anti-neutrophil cytoplasmic (ANCA), Anti-smooth muscle antibodies (ASMA), Anti-mitochondrial antibodies (AMA) and Anti liver-kidney microsomal (LKM-1), Anti-parietal (APA) by indirect immunofluorescence. Titers greater than or equal to 1:80 were considered positive. Extractabile Nuclear Antigen Antigen (ENA), Anticardiolipin (AclA), anti beta 2 glycoprotein (B2GPI) antibodies were tested by by enzyme-linked immunosorbent assay (ELISA).

RESULTS: We found total positivity of antibodies in TA patients of 54,1% (13/24), and it was significantly higher than in healthy individuals (6,3%; p<0.001). ANA was the most prevalent antibody, but we found no difference between two groups (p=0,12). ASMA was more common in TA patients (5/24) than in controls (p<0,001), and only one of ASMA positive patients met the necessary criteria for autoimmune hepatitis. The frequency of ANCA, APA, ENA, AclA, B2GPI did not differ significantly between examined groups. None of patient positive to LKM-1, AMA was found. Among our TA patients, inflammatory bowel disease was the most common OSAD(3/24).

CONCLUSIONS: We found that ASMA antibodies were more common in TA patients than in healthy controls. Although, its clinical significance in TA patients still needs further investigation.