735:
Relationship between Vitamin D status and atopic measures in patients with Strongyloidiasis
Monday, March 5, 2018
South Hall A2 (Convention Center)
Ishani Nautiyal, Lahari Rampur, MD, Sunit P. Jariwala, MD
RATIONALE: We previously associated vitamin D deficiency with increased allergic sensitization. Through another project, we diagnosed Strongyloidiasis in a large number of patients presenting with allergic symptoms. This study evaluates whether baseline vitamin D status correlates with atopy in our cohort of patients with Strongyloidiasis.

METHODS: We analyzed the charts of 58 patients with positive Strongyloides serology seen in our institution’s Allergy/Immunology clinics between 2011 and 2014. We included patients with available data regarding baseline serum 25-hydroxyvitamin D levels, baseline absolute eosinophil counts (AEC), baseline serum total IgE, and number of positive environmental skin prick tests (SPT) from a battery of 18 northeastern allergens. We stratified all patients into Vitamin D sufficient (>30 ng/mL) and Vitamin D deficient (<30 ng/mL) subgroups.

RESULTS: Among 58 patients, 9 were vitamin D sufficient and 49 were deficient (mean levels of 54.3 and 18.3 ng/mL, p<0.0001). In vitamin D sufficient patients, mean AEC was 0.76 K/μL, mean serum total IgE was 664 KU/L, and mean number of positive SPT was 8. In vitamin D deficient patients, mean AEC was 0.38 K/μL, mean serum total IgE was 638.9 KU/L, and mean number of positive SPT was 4.35. The 2-sample t-test revealed that the mean values of AEC, total IgE, and numbers of positive SPT were similar between the vitamin D sufficient and deficient patients (p>0.05).

CONCLUSIONS: We observed no association between Vitamin D deficiency and increased atopy in this patient cohort. Larger studies are necessary to evaluate how vitamin D status correlates with atopic measures in patients with Strongyloidiasis.