523:
Disease Burden of Chronic Rhinosinusitis (CRS) is as Severe as Other Serious Chronic Diseases
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Eric J. Schenkel, MD, John C. Messina Jr., PharmD, Andy Bodine, PhD, James S. Mcginley, PhD, R.J. Wirth, PhD, Ramy A. Mahmoud, MD, MPH
RATIONALE: CRS adversely affects health related quality of life (HRQoL); however, the burden compared to other diseases is not widely understood. Because the SF-36 (Medical Outcomes Study Short-Form, 36-item) is the most commonly used assessment of HRQoL, it allows standardized comparisons across a wide range of diseases.

METHODS: A literature search identified studies reporting SF-36 measurement of HRQoL in patients with CRS and 15 other chronic disorders. We compared the 8 health domains assessed by SF-36 (scores range from 0 [worse] to 100 [better]). The chronic conditions identified for comparison are chronic heart failure, chronic obstructive pulmonary disease (COPD), angina pectoris, back pain/sciatica, migraine, cancer, cancer-related pain symptoms, incontinence, acquired immune deficiency syndrome (AIDS), hyperlipidemia, clinical depression, diabetes, multiple sclerosis, epilepsy, and hepatitis.

RESULTS: CRS patients scored worse on bodily pain, general health, and mental health compared to most other serious diseases. Social functioning scores were lower for CRS (Mean=47.8) than any of the other chronic conditions (Mean scores ranged from 52.5 to 87.7). CRS sufferers reported bodily pain levels (Mean=39.8) consistent with cancer pain (Mean=39.6), incontinence (Mean=46.6), and AIDS (Mean=40.5). Average CRS scores for physical functioning (Mean=87.3) and physical role limitations (Mean=65.3) were comparable to migraine (Means: 82.4 and 62.2), epilepsy (Means: 78.9, 60.0), and hepatitis (Means: 79.3, 56.9). For emotional role limitations, CRS (Mean=84.0) was similar to hyperlipidemia (Mean=80.3).

CONCLUSIONS: CRS patients experience impairment of HRQoL comparable to other serious chronic diseases, with more pain and worse outlook on health than many other medical populations.