METHODS: All three generations of the IOW cohort have been assessed for asthma and allergic diseases and information on relevant environmental exposures have been collected. Recruitment and assessment of the IOW 3rd Generation cohort is ongoing; mothers have been assessed twice during pregnancy, while children are being assessed at 3, 12, 24, 36 and 72 months of age for allergic diseases wheeze, eczema and rhinitis using standardized questionnaires.
RESULTS: Since the inception of the 3rd Generation study in 2010, 452 children have been born into the cohort whose mothers or fathers are participants of the original IOW cohort. 367 children have been assessed at 3 months, 243 at 12 months, 151 at 24 months and 123 at 36 months. Wheeze occurred in 30.5% (107/351) at 3 months and 29.4% (95/323) at 12 months; eczema occurred in 21.4% (69/323) at 3 months and 24.8% (79/318) at 12 months and nasal symptoms 28.0% (99/353) at 3 months and 15.9% (43/271) at 24 months.
CONCLUSIONS: Period prevalence of current wheeze, eczema and nasal symptoms was high in the 3rd Generation cohort. The format of recruiting 3 generations of a cohort will provide valuable information on disease risk across generations and associated mechanisms for common diseases such as asthma and allergy.