762:
Analysis of Hazelnut Molecular Component Testing Reactivity
Monday, March 5, 2018
South Hall A2 (Convention Center)
Michelle L. Altrich, PhD
RATIONALE:

Hazelnut allergy, like other food allergies, can come in multiple forms ranging from local to system anaphylactic reactions. Molecular component testing allows risk stratification of patients.

METHODS: A retrospective review of national reference laboratory data was performed over an eighteen month period for IgE to rCor a 1, 8, 9, and 14 (Phadia), utilizing data with de-identified patient health information. Data was compiled into risk groups based on current research utilizing a cutoff of 0.1 kU/L as a positive test.

RESULTS: In the overall data set, 56% of samples were positive for either rCor a 9 or rCor a 14, which carries the highest risk for anaphylaxis. Only nine percent of samples were negative for all four of the hazelnut components. Samples that carried a low risk of reactions with only rCor a 1 positive represented 33 percent of the results. The remaining two percent had a variable risk of a serious reaction with only rCor a 8 being positive.

CONCLUSIONS: Molecular component allergy testing represents a major step forward in diagnosing and assessing risk for hazelnut allergic individuals. A significant rate of high risk identification indicates the importance of this information for patients and their families.