Analysis of Hazelnut Molecular Component Testing Reactivity
Monday, March 5, 2018
South Hall A2 (Convention Center)
Michelle L. Altrich, PhD

Hazelnut allergy, like other food allergies, can come in multiple forms ranging from local to system anaphylactic reactions. Molecular component testing allows risk stratification of patients.

METHODS: A retrospective review of national reference laboratory data was performed over an eighteen month period for IgE to rCor a 1, 8, 9, and 14 (Phadia), utilizing data with de-identified patient health information. Data was compiled into risk groups based on current research utilizing a cutoff of 0.1 kU/L as a positive test.

RESULTS: In the overall data set, 56% of samples were positive for either rCor a 9 or rCor a 14, which carries the highest risk for anaphylaxis. Only nine percent of samples were negative for all four of the hazelnut components. Samples that carried a low risk of reactions with only rCor a 1 positive represented 33 percent of the results. The remaining two percent had a variable risk of a serious reaction with only rCor a 8 being positive.

CONCLUSIONS: Molecular component allergy testing represents a major step forward in diagnosing and assessing risk for hazelnut allergic individuals. A significant rate of high risk identification indicates the importance of this information for patients and their families.