744:
Specific IgE for Staphyloccocus Aureus In Patients With Allergic Rhinitis
Monday, March 5, 2018
South Hall A2 (Convention Center)
Katia Guzman Avilan, MD, Sandra Nora Gonzalez-Diaz, MD, PhD, Alfredo Arias Cruz, MD FAAAAI, Alejandra Macias-Weinmann, MD, Rosa Ivett Guzman-Avilan, MD, Barbara Elizondo Villarreal, MD, Cindy Elizabeth de Lira-Quezada, MD, Rosalaura Virginia Villarreal-Gonzalez, MD, Carlos de la Cruz
RATIONALE: Bacterial infections can prevent expression of allergic phenotype in atopic individuals, whereas appearance of bacterial infections in individuals with developed allergic phenotype can exacerbate their allergic response. The most implicated microorganism in allergic rhinitis (AR) is Staphylococcus aureus (S. aureus), which sets super-antigens free that activate T cells, causing higher inflammatory response, that can lose control and may not respond to treatment. Purpose of this study was to compare specific IgE against S. aureus levels in patients with AR and controls as healthy patients.

METHODS: Transversal, retrospective and observational study. We selected 42 subjects between 18-75 years old with AR diagnosis or as control group, and analyzed serum for A, B, C and TSST specific IgE S. aureus toxins by InmunoCap. In controls, negative allergy was corroborated by clinical history and aeroallergen skin prick test.

RESULTS: Of the 42 analyzed samples, 20 corresponded to AR patients (65% male, and 35% female) and 22 controls (55% female and 45% male). For the AR group, the specific IgE S. aureus toxins ranges were reported as: A (0.00-1.67), B (0.00-41.20), C (0.00-38.40) and TSST (0.00-0.68); and for control group: A (0.00-0.38), B (0.00-0.39), C (0.00-0.85) and TSST (0.00-0.35). A Statistical difference was found in both groups in specific IgE for toxins A (P=0.036), B (P=0.041) and TSST (P=0.004).

CONCLUSIONS: Our data suggest that AR patients have higher levels of specific IgE for S. aureus. Therefore it is necessary to identify in patients who present with frequent exacerbations