L13:
Correlation between Overall Allergy Symptom Visual Analog Scale (VAS) Scores and Total Symptom Scores (TSS) in Subjects with Ragweed-Induced Allergic Rhinitis in an Environmental Exposure Chamber (EEC)
Monday, March 5, 2018
South Hall A2 (Convention Center)
Anne Marie Salapatek, MSc, PhD, Cherrie Small, MSc, PhD, Holly Lorentz, PhD, Erin Beattie, MSc, PhD, Victoria Nelson, MSc, Peter R. Couroux, MD
Rationale: The severity of allergic rhinitis is typically measured by TSS, scored on a Likert scale (0-3). However, VAS are increasingly being used in clinical trials. In the present study, we evaluated the correlation between an overall allergy symptoms VAS (0-100 mm) and TSS of allergic rhinitis subjects in the EEC over separate visits.

Methods: A total of 78 subjects with allergic rhinitis were exposed to ragweed allergen in the EEC and subsequently every 13 (+5) days thereafter for a total of 3 visits. During the EEC visits, subjects recorded their individual nasal and ocular symptoms to achieve a TSS as well as their overall allergy symptoms on a VAS using an electronic diary (ePDAT®) prior to EEC entry and every 30 minutes over a 2 hour period.

Results: Both TSS and VAS increased and peaked over time showing similar trends between all 3 visits. The average TSS and VAS showed a highly positive correlation at all 3 visits (Visit 1: r = 0.7765, Visit 2: r = 0.6433, Visit 3: r = 0.7316, all p-values < 0.0001). When the correlation between TSS and VAS scores were analyzed over time, once again, high correlations were seen (Visit 1: r = 0.9948, Visit 2: r = 0.9873, Visit 3: r = 0.9863, all p-values < 0.0001).

Conclusions: These findings suggest that VAS can also be used as an alternative to total scores of individual nasal and ocular symptom scores symptoms correlating with disease severity and detecting symptom variation in allergic rhinitis individuals.