Best Practices in Recruitment of the First US-Based Atopic Dermatitis Cohort: The Mechanisms of Progression of Atopic Dermatitis to Asthma in Children (MPAACH).
Monday, March 5, 2018
South Hall A2 (Convention Center)
Asel Baatyrbek-kyzy, BS, Rosario Alarcon, BS, Alexandria Patterson, BS, Kristina Keidel, BA, John Kroner, MS, Gurjit K. Khurana Hershey, MD PhD FAAAAI, Jocelyn M. Biagini Myers, PhD
Rationale: We determined best practices in recruiting the first US-based prospective atopic dermatitis cohort, the Mechanisms of Progression of Atopic Dermatitis (AD) to Asthma in Children (MPAACH).

Methods: Children aged 1-2 with and ICD code for AD were identified from Cincinnati Children’s Hospital medical records or from the general population in response to flyers posted in pediatrician offices, pharmacies and public message boards. Participants identified from the medical record received an invitation letter or were verbally presented the study in the outpatient setting.

Results: A total of 4089 phone calls were made to 1110 potential participants. Of the 765 participants contacted (68.9%), 261 (34.1%) met the inclusion criteria. Of these, 183 (70.1%) completed their first visit), 276 (36.1%) were not eligible and 228 (29.8%) refused. The mean number of calls to those that were eligible, not eligible and refused was 2.5, 2.1 and 3.3, respectively. Of all calls placed in the morning, afternoon, evening and weekend, 5.9%, 6.5%, 6.8% and 4.8%, respectively, resulted in a scheduled visit. An additional 52 participants were enrolled from advertising; these children were more likely to have private insurance (74% vs. 21%, p<0.001), be non-black (71% vs. 26%, p<0.001), and have higher SCORAD scores (26.8 vs. 20.8, p=0.03).

Conclusions: Successful recruitment of toddlers for an AD cohort requires mailed letters, phone calls and public advertising; at least 3 phone calls spread over daytime, evenings and weekends are required to maximize recruitment. Participants that self-select tend to have more severe AD.